Gene expression across mammalian organ development

Cardoso-Moreira, Margarida, Halbert, Jean, Valloton, Delphine, Velten, Britta, Chen, Chunyan, Shao, Yi, Liechti, Angélica, Ascenção, Kelly, Rummel, Coralie, Ovchinnikova, Svetlana, Mazin, Pavel V., Xenarios, Ioannis, Harshman, Keith, Mort, Matthew ORCID: https://orcid.org/0000-0002-3986-0935, Cooper, David N. ORCID: https://orcid.org/0000-0002-8943-8484, Sandi, Carmen, Soares, Michael J., Ferreira, Paula G., Afonso, Sandra, Carneiro, Miguel, Turner, James M. A., VandeBerg, John L., Fallahshahroudi, Amir, Jensen, Per, Behr, Rüdiger, Lisgo, Steven, Lindsay, Susan, Khaitovich, Philipp, Huber, Wolfgang, Baker, Julie, Anders, Simon, Zhang, Yong E. and Kaessmann, Henrik 2019. Gene expression across mammalian organ development. Nature 571 , 505 - 509. 10.1038/s41586-019-1338-5

Preview

PDF - Accepted Post-Print Version Download (423kB) | Preview

Abstract

The evolution of gene expression in mammalian organ development remains largely uncharacterized. Here we report the transcriptomes of seven organs (cerebrum, cerebellum, heart, kidney, liver, ovary and testis) across developmental time points from early organogenesis to adulthood for human, rhesus macaque, mouse, rat, rabbit, opossum and chicken. Comparisons of gene expression patterns identified correspondences of developmental stages across species, and differences in the timing of key events during the development of the gonads. We found that the breadth of gene expression and the extent of purifying selection gradually decrease during development, whereas the amount of positive selection and expression of new genes increase. We identified differences in the temporal trajectories of expression of individual genes across species, with brain tissues showing the smallest percentage of trajectory changes, and the liver and testis showing the largest. Our work provides a resource of developmental transcriptomes of seven organs across seven species, and comparative analyses that characterize the development and evolution of mammalian organs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Nature Research
ISSN:	0028-0836
Date of First Compliant Deposit:	10 July 2019
Date of Acceptance:	31 May 2019
Last Modified:	23 Nov 2024 08:00
URI:	https://orca.cardiff.ac.uk/id/eprint/124116

Citation Data

Cited 213 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item