A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas

Smith, Keith, El-Hiti, Gamal A., Hegazy, Amany Saber and Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897 2011. A simple and convenient one-pot synthesis of substituted isoindolin-1-ones via lithiation, substitution and cyclization of N'-benzyl-N,N-dimethylureas. Beilstein Journal of Organic Chemistry 7 , pp. 1219-1227. 10.3762/bjoc.7.142

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Abstract

Lithiation of N'-benzyl-N,N-dimethylurea and its substituted derivatives with t-BuLi (3.3 equiv) in anhydrous THF at 0 °C followed by reaction with various electrophiles afforded a range of 3-substituted isoindolin-1-ones in high yields.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	N'-benzyl-N,N-dimethylureas; isoindolin-1-ones; directed lithiation; electrophiles; substitution; synthesis
Publisher:	Beilstein-Institut
ISSN:	1860-5397
Date of First Compliant Deposit:	30 March 2016
Last Modified:	12 May 2023 01:29
URI:	https://orca.cardiff.ac.uk/id/eprint/12506

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