Iron-catalyzed borrowing hydrogen β-C(sp3)-methylation of alcohols

Polidano, Kurt, Williams, Jonathan M. J. and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2019. Iron-catalyzed borrowing hydrogen β-C(sp3)-methylation of alcohols. ACS Catalysis 9 (9) , pp. 8575-8580. 10.1021/acscatal.9b02461

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Abstract

Herein we report the iron-catalyzed β-C(sp3)-methylation of primary alcohols using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	American Chemical Society
ISSN:	2155-5435
Funders:	EPSRC
Date of First Compliant Deposit:	22 August 2019
Date of Acceptance:	15 August 2019
Last Modified:	03 May 2023 08:34
URI:	https://orca.cardiff.ac.uk/id/eprint/125064

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