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γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity

Nguyen, Cuong Thach, Maverakis, Emanual, Eberl, Matthias and Adamopoulos, Iannis E. 2019. γδ T cells in rheumatic diseases: from fundamental mechanisms to autoimmunity. Seminars in Immunopathology 41 (5) , pp. 595-605. 10.1007/s00281-019-00752-5

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The innate and adaptive arms of the immune system tightly regulate immune responses in order to maintain homeostasis and host defense. The interaction between those two systems is critical in the activation and suppression of immune responses which if unchecked may lead to chronic inflammation and autoimmunity. γδ T cells are non-conventional lymphocytes, which express T cell receptor (TCR) γδ chains on their surface and straddle between innate and adaptive immunity. Recent advances in of γδ T cell biology have allowed us to expand our understanding of γδ T cell in the dysregulation of immune responses and the development of autoimmune diseases. In this review, we summarize current knowledge on γδ T cells and their roles in skin and joint inflammation as commonly observed in rheumatic diseases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer Verlag (Germany)
ISSN: 1863-2297
Date of Acceptance: 29 August 2019
Last Modified: 11 Sep 2020 08:39

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