Valle-Encinas, Eider and Dale, Trevor C. ORCID: https://orcid.org/0000-0002-4880-9963 2020. Wnt ligand and receptor patterning in the liver. Current Opinion in Cell Biology 62 , pp. 17-25. 10.1016/j.ceb.2019.07.014 |
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Official URL: http://dx.doi.org/10.1016/j.ceb.2019.07.014
Abstract
In the liver, the tight spatiotemporal regulation of Wnt/β-catenin signaling is required to establish and maintain a metabolic form of tissue polarity termed zonation. In this review, we discuss the latest technologies applied in the study of liver zonation and provide a summary of the Wnt ligand and receptor expression patterns in the hepatic lobule. We further discuss the mechanisms, by which Wnt instructive cues might be spatially confined and propagated along the central vein-portal triad axis.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Biosciences European Cancer Stem Cell Research Institute (ECSCRI) |
Publisher: | Elsevier |
ISSN: | 0955-0674 |
Date of First Compliant Deposit: | 10 October 2019 |
Date of Acceptance: | 24 July 2019 |
Last Modified: | 13 Nov 2023 09:58 |
URI: | https://orca.cardiff.ac.uk/id/eprint/125974 |
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