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Cluster headache: an overview of established and emerging treatments

Al-Ansari, A. and Robertson, N. P. ORCID: 2019. Cluster headache: an overview of established and emerging treatments. Journal of Neurology 266 (11) , pp. 2890-2892. 10.1007/s00415-019-09548-x

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Cluster headache is a rare but disabling neurological disorder, characterised, according to the International Classification of Headache Disorders-3 (ICHD-3), by unilateral severe headache with associated autonomic features and agitation. Despite proven abortive and preventive treatments, many cases remain refractory, leading to adverse psychosocial and employment outcomes. Understanding the efficacy of current and emerging therapies may help to improve clinical management of such cases. This month’s journal club reviews three papers relating to treatment of cluster headache. The first explores the effectiveness and adverse effects of a range of acute treatments for cluster headache, based on a large international sample. The second is a pooled analysis of two previous trials evaluating non-invasive vagus nerve stimulation (nVNS) as an acute treatment for cluster headache. The third paper describes a double-blind, randomised, placebo-controlled study assessing the monoclonal antibody galcanezumab as a preventive agent for cluster headache.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Springer Verlag (Germany)
ISSN: 0340-5354
Date of First Compliant Deposit: 15 October 2019
Date of Acceptance: 30 September 2019
Last Modified: 08 May 2023 04:50

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