An analysis of Cellular Communication Network (CCN) proteins as candidate mediators of postpartum psychosis risk

Davies, William ORCID: https://orcid.org/0000-0002-7714-2440 2019. An analysis of Cellular Communication Network (CCN) proteins as candidate mediators of postpartum psychosis risk. Frontiers in Psychiatry 10 , 876. 10.3389/fpsyt.2019.00876

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Abstract

Postpartum (or puerperal) psychosis (PP) is a severe psychiatric condition associated with hallucinations, delusions, cognitive disorganisation and mood problems, which affects approximately 1-2 out of every 1000 new mothers shortly after childbirth. Whilst the risk factors for, and co-morbidities of, PP are relatively well-defined, currently the pathophysiology underlying the disorder is very poorly-specified. Here, I argue, on the basis of multiple lines of new evidence, that altered expression of the Cellular Communication Network (CCN) factor proteins (and of the heterodimerising CCN2 and CCN3 proteins in particular), may be associated with, and possibly causal for, increased PP risk. Future preclinical and clinical studies should aim to test this hypothesis as empirical support for it would provide much-needed clues regarding the biological substrates of PP, and could point to predictive biomarkers for the condition.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Medicine Neuroscience and Mental Health Research Institute (NMHRI) MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Frontiers Media
ISSN:	1664-0640
Funders:	MRC
Date of First Compliant Deposit:	6 November 2019
Date of Acceptance:	6 November 2019
Last Modified:	28 Sep 2023 22:10
URI:	https://orca.cardiff.ac.uk/id/eprint/126616

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