One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N'-benzyl-N,N-dimethylureas

Smith, Keith ORCID: https://orcid.org/0000-0003-4838-5651, El-Hiti, Gamal A. and Hegazy, Amany Saber 2010. One-pot synthesis of substituted isoindolin-1-ones via lithiation and substitution of N'-benzyl-N,N-dimethylureas. Chemical Communications 46 (16) , pp. 2790-2792. 10.1039/B926983E

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Abstract

Lithiation of various N′-benzyl-N,N-dimethylureas with t-BuLi (3.3 mole equivalents) in anhydrous THF at 0 °C followed by reactions with various electrophiles afforded the corresponding 3-substituted isoindolin-1-ones in high yields.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Subjects:	Q Science > QD Chemistry
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Last Modified:	05 Aug 2026 04:40
URI:	https://orca.cardiff.ac.uk/id/eprint/12723

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