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PPARβ/δ: A master regulator of mesenchymal stem cell functions

Djouad, Farida, Ipseiz, Natacha ORCID:, Luz-Crawford, Patricia, Scholtysek, Carina, Kroenke, Gerhard and Jorgensen, Christian 2017. PPARβ/δ: A master regulator of mesenchymal stem cell functions. Biochimie 136 , pp. 55-58. 10.1016/j.biochi.2016.11.011

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Peroxisome proliferator-activated receptors (PPARs) have emerged as key regulators of physiological and immunological processes. Recently, one of their members PPARβ/δ has been identified as major player in the maintenance of bone homeostasis, by promoting Wnt signalling activity in osteoblast and mesenchymal stem cells (MSC). PPARβ/δ not only controls the fate of MSC but also regulates their immunosuppressive properties by directly modulating their NF-κB activity. In this review, we discuss how the regulation of PPARβ/δ provides an innovative strategy for an optimisation of MSC-based therapy.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Elsevier
Date of Acceptance: 22 November 2016
Last Modified: 26 Oct 2022 08:28

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