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Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis

Ipseiz, Natacha, Scholtysek, Carina, Culemann, Stephan and Krönke, Gerhard 2014. Adopted orphans as regulators of inflammation, immunity and skeletal homeostasis. Swiss Medical Weekly 144 , w14055. 10.4414/smw.2014.14055

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Adopted orphan nuclear receptors, such as peroxisome proliferator-activated receptors (PPARs) and liver X receptors (LXRs), have emerged as key regulators of inflammation and immunity and likewise control skeletal homeostasis. These properties render them attractive targets for the therapy of various inflammatory and autoimmune diseases affecting the musculoskeletal system. This review summarises the current knowledge on the role of these families of receptors during innate and adaptive immunity as well as during the control of bone turnover and discuss the potential use of targeting these molecules during the treatment of chronic diseases such as osteoarthritis, rheumatoid arthritis and osteoporosis.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Publisher: Swiss Medical Publishers
ISSN: 1424-7860
Last Modified: 16 Jan 2020 16:53

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