N-Heterocyclic carbene acyl anion organocatalysis by ball-milling

Nicholson, William I., Seastram, Alex C., Iqbal, Saqib A., Reed-Berendt, Benjamin G., Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 and Browne, Duncan L. ORCID: https://orcid.org/0000-0002-8604-229X 2020. N-Heterocyclic carbene acyl anion organocatalysis by ball-milling. ChemSusChem 13 (1) , pp. 131-135. 10.1002/cssc.201902346

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Abstract

The ability to conduct N‐heterocyclic carbene‐catalysed acyl anion chemistry under ball‐milling conditions is reported for the first time. This process has been exemplified through applications to intermolecular‐benzoin, intramolecular‐benzoin, intermolecular‐Stetter and intramolecular‐Stetter reactions including asymmetric examples and demonstrates that this mode of mechanistically complex organocatalytic reaction can operate under solvent‐minimised conditions.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	Wiley
ISSN:	1864-5631
Funders:	EPSRC
Date of First Compliant Deposit:	3 January 2020
Date of Acceptance:	25 October 2019
Last Modified:	25 Jul 2023 16:15
URI:	https://orca.cardiff.ac.uk/id/eprint/128174

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