Exploring the reactivity and biological effects of heteroleptic N-Heterocyclic carbene gold(I)-Alkynyl complexes

Oberkofler, Jens, Aikman, Brech, Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384, Pöthig, Alexander, Platts, James ORCID: https://orcid.org/0000-0002-1008-6595, Casini, Angela ORCID: https://orcid.org/0000-0003-1599-9542 and Kühn, Fritz E. 2020. Exploring the reactivity and biological effects of heteroleptic N-Heterocyclic carbene gold(I)-Alkynyl complexes. European Journal of Inorganic Chemistry 2020 (11-12) , pp. 1040-1051. 10.1002/ejic.201901043

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Abstract

Two families of heteroleptic N‐heterocyclic carbene gold(I)‐alkynyl complexes have been synthesized and characterized by different methods. Their reactivity with model thiols has been studied by NMR spectroscopy and DFT calculations. Moreover, preliminary studies on the compounds' reactivity with DNA and antiproliferative effects have been conducted.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Advanced Research Computing @ Cardiff (ARCCA)
Publisher:	Wiley
ISSN:	1434-1948
Funders:	European Union H2020
Date of First Compliant Deposit:	6 January 2020
Date of Acceptance:	5 December 2019
Last Modified:	05 Jan 2024 07:45
URI:	https://orca.cardiff.ac.uk/id/eprint/128228

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