Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: An arterial spin labeling study

Saxena, Neeraj ORCID:, Gili, Tommaso ORCID:, Diukova, Ana, Huckle, Danielle, Hall, Judith E. ORCID: and Wise, Richard G. ORCID: 2019. Mild propofol sedation reduces frontal lobe and thalamic cerebral blood flow: An arterial spin labeling study. Frontiers in Physiology 10 , 1541. 10.3389/fphys.2019.01541

[thumbnail of Wise. Mild]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (1MB) | Preview


Mechanisms of anesthetic drug-induced sedation and unconsciousness are still incompletely understood. Functional neuroimaging modalities provide a window to study brain function changes during anesthesia allowing us to explore the sequence of neuro-physiological changes associated with anesthesia. Cerebral perfusion change under an assumption of intact neurovascular coupling is an indicator of change in large-scale neural activity. In this experiment, we have investigated resting state cerebral blood flow (CBF) changes in the human brain during mild sedation, with propofol. Arterial spin labeling (ASL) provides a non-invasive, reliable, and robust means of measuring cerebral blood flow (CBF) and can therefore be used to investigate central drug effects. Mild propofol sedation-related CBF changes were studied at rest (n = 15), in a 3 T MR scanner using a PICORE-QUIPSS II ASL technique. CBF was reduced in bilateral paracingulate cortex, premotor cortex, Broca’s areas, right superior frontal gyrus and also the thalamus. This cerebral perfusion study demonstrates that propofol induces suppression of key cortical (frontal lobe) and subcortical (thalamus) regions during mild sedation.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Frontiers Media
ISSN: 1664-042X
Funders: Wellcome Trust
Date of First Compliant Deposit: 6 January 2020
Date of Acceptance: 5 December 2019
Last Modified: 23 May 2024 01:05

Citation Data

Cited 5 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics