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Real-time microscopic observation of biological interactions with microwave fields

Williams, C.F. ORCID:, Lees, J. ORCID:, Lloyd, D., Geroni, G.M., Jones, S., Ambala, S., Baradat, W., Comat, G., Aboubakary, A., Voisin, S. and Porch, A. ORCID: 2018. Real-time microscopic observation of biological interactions with microwave fields. Presented at: International Microwave Biomedical Conference (IMBioC), Philadelphia, USA, 14-15 Jun 2018. International Microwave Biomedical Conference (IMBioC). IEEE, p. 199. 10.1109/IMBIOC.2018.8428902

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Here we describe the design and fabrication of novel coplanar waveguide applicators, which facilitate real-time observation of separated electric and magnetic field effects on biological systems. S 11 parameters and temperature changes across these waveguides was characterized, and the feasibility of simultaneous microwave excitation and microscope observation was confirmed by tracking the motility of a protozoan fish parasite, Spironucleus vortens. This paves the way for in-depth studies into the biophysical effects of electromagnetic fields (up to 3GHz) on a range of biological systems. Applications extend from optimization of therapeutic intervention (e.g. thermal ablation and elec-troporation) to understanding putatively hazardous effects from environmental sources of non-ionizing radiation.

Item Type: Conference or Workshop Item (Paper)
Date Type: Published Online
Status: Published
Schools: Engineering
Publisher: IEEE
ISBN: 9781538659199
Last Modified: 10 Dec 2022 02:19

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