Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Prince, Luke Y., Bacon, Travis J., Tigaret, Cezar M. ORCID: and Mellor, Jack R. 2016. Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit. Frontiers in Synaptic Neuroscience 8 , 32. 10.3389/fnsyn.2016.00032

[thumbnail of Prince Mellor 2016 Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (967kB) | Preview


The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Publisher: Frontiers
ISSN: 1663-3563
Date of First Compliant Deposit: 14 January 2020
Date of Acceptance: 20 September 2016
Last Modified: 05 May 2023 02:07

Citation Data

Cited 22 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics