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Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit

Prince, Luke Y., Bacon, Travis J., Tigaret, Cezar M. ORCID: https://orcid.org/0000-0001-5848-6697 and Mellor, Jack R. 2016. Neuromodulation of the feedforward dentate gyrus-CA3 microcircuit. Frontiers in Synaptic Neuroscience 8 , 32. 10.3389/fnsyn.2016.00032

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Abstract

The feedforward dentate gyrus-CA3 microcircuit in the hippocampus is thought to activate ensembles of CA3 pyramidal cells and interneurons to encode and retrieve episodic memories. The creation of these CA3 ensembles depends on neuromodulatory input and synaptic plasticity within this microcircuit. Here we review the mechanisms by which the neuromodulators aceylcholine, noradrenaline, dopamine, and serotonin reconfigure this microcircuit and thereby infer the net effect of these modulators on the processes of episodic memory encoding and retrieval.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Neuroscience and Mental Health Research Institute (NMHRI)
Medicine
Publisher: Frontiers
ISSN: 1663-3563
Date of First Compliant Deposit: 14 January 2020
Date of Acceptance: 20 September 2016
Last Modified: 26 Oct 2022 08:52
URI: https://orca.cardiff.ac.uk/id/eprint/128520

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