Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Metal ions and metal complexes in Alzheimer's disease

Spinello, Angelo, Bonsignore, Riccardo ORCID: https://orcid.org/0000-0003-2699-4384, Barone, Giampaolo, Keppler, Bernhard K. and Terenzi, Alessio 2016. Metal ions and metal complexes in Alzheimer's disease. Current Pharmaceutical Design 22 (26) , pp. 3996-4010. 10.2174/1381612822666160520115248

Full text not available from this repository.

Abstract

Background: Alzheimer’s disease (AD) is the most common form of dementia that seriously affects daily life. Even if AD pathogenesis is still subject of debate, it is generally accepted that cerebral cortex plaques formed by aggregated amyloid-β (Aβ) peptides can be considered a characteristic pathological hallmark. It is well known that metal ions play an important role in the aggregation process of Aβ. Methods: This review focuses on the anti-Aβ aggregation activity of chelating ligands as well as on the use of metal complexes as diagnostic probes and as potential drugs. Conclusion: While chelating agents, such as curcumin or flavonoid derivatives, are currently used to capture metal ions responsible for Aβ aggregation, the potential application of platinum, ruthenium and cobalt complexes, among others, of several heterocyclic ligands, represents a promising new strategy to fight AD.

Item Type: Article
Status: Published
Schools: Chemistry
ISSN: 1873-4286
Date of Acceptance: 17 May 2016
Last Modified: 07 Nov 2022 09:19
URI: https://orca.cardiff.ac.uk/id/eprint/128685

Citation Data

Cited 28 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item