Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Lactose as a "Trojan horse" for quantum dot cell rransport

Benito-Alifonso, David, Tremel, Shirley, Hou, Bo ORCID: https://orcid.org/0000-0001-9918-8223, Lockyear, Harriet, Mantell, Judith, Fermin, David J., Verkade, Paul, Berry, Monica and Galan, M. Carmen 2014. Lactose as a "Trojan horse" for quantum dot cell rransport. Angewandte Chemie International Edition 53 (3) , pp. 810-814. 10.1002/anie.201307232

[thumbnail of Benito-Alifonso_et_al-2014-Angewandte_Chemie_International_Edition.pdf] PDF - Published Version
Available under License Creative Commons Attribution.

Download (0B)

Abstract

A series of glycan‐coated quantum dots were prepared to probe the effect of glycan presentation in intracellular localization in HeLa and SV40 epithelial cells. We show that glycan density mostly impacts on cell toxicity, whereas glycan type affects the cell uptake and intracellular localization. Moreover, we show that lactose can act as a “Trojan horse” on bi‐functionalized QDs to help intracellular delivery of other non‐internalizable glycan moieties and largely avoid the endosomal/lysosomal degradative pathway.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Physics and Astronomy
Publisher: Wiley
ISSN: 1433-7851
Date of First Compliant Deposit: 25 February 2020
Last Modified: 05 Nov 2022 08:04
URI: https://orca.cardiff.ac.uk/id/eprint/129509

Citation Data

Cited 55 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics