Navarrete, Miguel, Valderrama, Mario and Lewis, Penelope A. ORCID: https://orcid.org/0000-0003-1793-3520 2020. The role of slow-wave sleep rhythms in the corticalhippocampal loop for memory consolidation. Current Opinion in Behavioral Sciences 32 , pp. 102-110. 10.1016/j.cobeha.2020.02.006 |
PDF
- Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (364kB) |
Abstract
Memory consolidation during slow-wave sleep is supported by slow oscillations (SOs), spindles, and hippocampal ripples. Recent evidence in both rodents and humans has demonstrated that consolidation is mediated by a bidirectional hippocampal-cortical loop. Here, we discuss oscillatory mechanisms by which the interaction of these non-REM oscillations may provide an appropriate neural framework for both the TOP-DOWN and the BOTTOM-UP processes in this loop. We also discuss how non-REM oscillations promote cortical plasticity for new memories, while simultaneously downregulating the representations of information in hippocampal networks. Finally, we point out that not all individual instances of non-REM oscillations play a role in the consolidation process. Instead, the capacity of these rhythms to support memory is determined by a triple SOspindle- ripple coupling provided by thalamocortical dynamics. Importantly, large, spatially synchronised SOs promote thalamic downstates, and spindles, boosting the probability of this triple coupling.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Psychology Cardiff University Brain Research Imaging Centre (CUBRIC) |
Publisher: | Elsevier |
ISSN: | 2352-1546 |
Date of First Compliant Deposit: | 2 March 2020 |
Date of Acceptance: | 13 February 2020 |
Last Modified: | 02 Dec 2024 15:30 |
URI: | https://orca.cardiff.ac.uk/id/eprint/130078 |
Citation Data
Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |