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The role of slow-wave sleep rhythms in the corticalhippocampal loop for memory consolidation

Navarrete, Miguel, Valderrama, Mario and Lewis, Penelope A. ORCID: 2020. The role of slow-wave sleep rhythms in the corticalhippocampal loop for memory consolidation. Current Opinion in Behavioral Sciences 32 , pp. 102-110. 10.1016/j.cobeha.2020.02.006

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Memory consolidation during slow-wave sleep is supported by slow oscillations (SOs), spindles, and hippocampal ripples. Recent evidence in both rodents and humans has demonstrated that consolidation is mediated by a bidirectional hippocampal-cortical loop. Here, we discuss oscillatory mechanisms by which the interaction of these non-REM oscillations may provide an appropriate neural framework for both the TOP-DOWN and the BOTTOM-UP processes in this loop. We also discuss how non-REM oscillations promote cortical plasticity for new memories, while simultaneously downregulating the representations of information in hippocampal networks. Finally, we point out that not all individual instances of non-REM oscillations play a role in the consolidation process. Instead, the capacity of these rhythms to support memory is determined by a triple SOspindle- ripple coupling provided by thalamocortical dynamics. Importantly, large, spatially synchronised SOs promote thalamic downstates, and spindles, boosting the probability of this triple coupling.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher: Elsevier
ISSN: 2352-1546
Date of First Compliant Deposit: 2 March 2020
Date of Acceptance: 13 February 2020
Last Modified: 06 Nov 2023 21:18

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