Application of smooth particle hydrodynamics method for modelling blood flow with thrombus formation

Al-Saad, M., Suarez, C. A., Obeidat, A., Bordas, S. P. A. ORCID: https://orcid.org/0000-0001-8634-7002 and Kulasegaram, S. ORCID: https://orcid.org/0000-0002-9841-1339 2020. Application of smooth particle hydrodynamics method for modelling blood flow with thrombus formation. Computer Modeling in Engineering & Sciences 122 (3) , pp. 831-862. 10.32604/cmes.2020.08527

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Abstract

Thrombosis plays a crucial role in atherosclerosis or in haemostasis when a blood vessel is injured. This article focuses on using a meshless particle-based Lagrangian numerical technique, the smoothed particles hydrodynamic (SPH) method, to study the flow behaviour of blood and to explore the flow parameters that induce formation of a thrombus in a blood vessel. Due to its simplicity and effectiveness, the SPH method is employed here to simulate the process of thrombogenesis and to study the effect of various blood flow parameters. In the present SPH simulation, blood is modelled by two sets of particles that have the characteristics of plasma and of platelet, respectively. To simulate coagulation of platelets which leads to a thrombus, the so-called adhesion and aggregation mechanisms of the platelets during this process are modelled by an inter-particle force model. The transport of platelets in the flowing blood, platelet adhesion and aggregation processes are coupled with viscous blood flow for various low Reynolds number scenarios. The numerical results are compared with the experimental observations and a good agreement is found between the simulated and experimental results.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Engineering Advanced Research Computing @ Cardiff (ARCCA)
Publisher:	Tech Science Press
ISSN:	1526-1506
Date of First Compliant Deposit:	5 March 2020
Date of Acceptance:	16 January 2020
Last Modified:	06 Nov 2023 21:18
URI:	https://orca.cardiff.ac.uk/id/eprint/130125

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