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RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation

Galino, Jorge, Cervellini, Ilaria, Zhu, Ning, Stöberl, Nina, Hütte, Meike, Fricker, Florence R., Lee, Garrett, McDermott, Lucy, Lalli, Giovanna and Bennett, David L.H. 2019. RalGTPases contribute to Schwann cell repair after nerve injury via regulation of process formation. Journal of Cell Biology 218 (7) , pp. 2370-2387. 10.1083/jcb.201811002

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Abstract

RalA and RalB are small GTPases that are involved in cell migration and membrane dynamics. We used transgenic mice in which one or both GTPases were genetically ablated to investigate the role of RalGTPases in the Schwann cell (SC) response to nerve injury and repair. RalGTPases were dispensable for SC function in the naive uninjured state. Ablation of both RalA and RalB (but not individually) in SCs resulted in impaired axon remyelination and target reinnervation following nerve injury, which resulted in slowed recovery of motor function. Ral GTPases were localized to the leading lamellipodia in SCs and were required for the formation and extension of both axial and radial processes of SCs. These effects were dependent on interaction with the exocyst complex and impacted on the rate of SC migration and myelination. Our results show that RalGTPases are required for efficient nerve repair by regulating SC process formation, migration, and myelination, therefore uncovering a novel role for these GTPases.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Rockefeller University Press
ISSN: 0021-9525
Date of First Compliant Deposit: 22 April 2020
Date of Acceptance: 15 May 2019
Last Modified: 05 May 2023 12:39
URI: https://orca.cardiff.ac.uk/id/eprint/131125

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