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Determinants of lamina cribrosa depth in healthy Asian eyes: the Singapore Epidemiology Eye Study

Tun, Tin A., Wang, Xiaofei, Baskaran, Mani, Nongpiur, Monisha Esther, Tham, Yih Chung, Nguyen, Duc Quang, Strouthidis, Nicholas G., Aung, Tin, Cheng, Ching-Yu, Boote, Craig and Girard, Michael J. A. 2021. Determinants of lamina cribrosa depth in healthy Asian eyes: the Singapore Epidemiology Eye Study. British Journal of Ophthalmology 105 (3) , pp. 367-373. 10.1136/bjophthalmol-2020-315840

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Aim To investigate the determinants of lamina cribrosa depth (LCD) in healthy eyes of Chinese and Indian Singaporean adults. Methods The optic nerve head (ONH) of the right eye of 1396 subjects (628 Chinese and 768 Indian subjects) was imaged with optical coherence tomography (OCT, Spectralis, Heidelberg, Germany). LCD was defined as the distance from the Bruch’s membrane opening (LCD-BMO) or the peripapillary sclera (LCD-PPS) reference plane to the laminar surface. A linear regression model was used to evaluate the relationship between the LCD and its determinants. Results Both LCDs were significantly different between the two races (LCD-BMO: 421.95 (95% CI 365.32 to 491.79) µm in Chinese vs 430.39 (367.46–509.81) µm in Indians, p=0.021; and LCD-PPS: 353.34 (300.98–421.45) µm in Chinese vs 376.76 (313.39–459.78) µm in Indians, p<0.001). In the multivariable regression analysis, the LCD-PPS of the whole cohort was independently associated with females (β=−31.93, p<0.001), Indians subjects (β=21.39, p=0.004) (Chinese as the reference), axial length (Axl) (β=−6.68, p=0.032), retinal nerve fibre layer thickness (RNFL) (β=0.71, p=0.019), choroidal thickness (ChT) (β=0.41, p<0.001), vertical cup disc ratio (VCDR) (β=24.42, p<0.001) and disc size (β=−60.75, p=0.001). For every 1 year older in age, the LCD-PPS was deeper on average by 1.95 µm in Chinese subjects (p=0.01) but there was no association in Indians subjects (p=0.851). Conclusions The LCD was influenced by age, gender, race, Axl, RNFL, ChT, VCDR and disc size. This normative LCD database may facilitate a more accurate assessment of ONH cupping using OCT in Asian populations.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Optometry and Vision Sciences
Publisher: BMJ Publishing Group
ISSN: 0007-1161
Date of First Compliant Deposit: 28 May 2020
Date of Acceptance: 29 April 2020
Last Modified: 07 Oct 2021 17:51

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