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Optimization of image reconstruction for 90 Y selective internal eadiotherapy on a lutetium yttrium orthosilicate PET/CT system using a Bayesian penalized likelihood reconstruction algorithm

Rowley, Lisa M., Bradley, Kevin M. ORCID: https://orcid.org/0000-0003-1911-3382, Boardman, Philip, Hallam, Aida and McGowan, Daniel R. 2017. Optimization of image reconstruction for 90 Y selective internal eadiotherapy on a lutetium yttrium orthosilicate PET/CT system using a Bayesian penalized likelihood reconstruction algorithm. Journal of Nuclear Medicine 58 (4) , pp. 658-664. 10.2967/jnumed.116.176552

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Abstract

Imaging on a γ-camera with 90Y after selective internal radiotherapy (SIRT) may allow for verification of treatment delivery but suffers relatively poor spatial resolution and imprecise dosimetry calculation. 90Y PET/CT imaging is possible on 3-dimensional, time-of-flight machines; however, images are usually poor because of low count statistics and noise. A new PET reconstruction software using a Bayesian penalized likelihood (BPL) reconstruction algorithm (termed Q.Clear) was investigated using phantom and patient scans to optimize the reconstruction for post-SIRT imaging and clarify whether BPL leads to an improvement in clinical image quality using 90Y. Methods: Phantom studies over an activity range of 0.5–4.2 GBq were performed to assess the contrast recovery, background variability, and contrast-to-noise ratio for a range of BPL and ordered-subset expectation maximization (OSEM) reconstructions on a PET/CT scanner. Patient images after SIRT were reconstructed using the same parameters and were scored and ranked on the basis of image quality, as assessed by visual evaluation, with the corresponding SPECT/CT Bremsstrahlung images by 2 experienced radiologists. Results: Contrast-to-noise ratio was significantly better in BPL reconstructions when compared with OSEM in phantom studies. The patient-derived BPL and matching Bremsstrahlung images scored higher than OSEM reconstructions when scored by radiologists. BPL with a β value of 4,000 was ranked the highest of all images. Deadtime was apparent in the system above a total phantom activity of 3.3 GBq. Conclusion: BPL with a β value of 4,000 is the optimal image reconstruction in PET/CT for confident radiologic reading when compared with other reconstruction parameters for 90Y imaging after SIRT imaging. Activity in the field of view should be below 3.3 GBq at the time of PET imaging to avoid deadtime losses for this scanner.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Society of Nuclear Medicine
ISSN: 0161-5505
Date of Acceptance: 8 September 2016
Last Modified: 07 Nov 2022 10:21
URI: https://orca.cardiff.ac.uk/id/eprint/132006

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