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Evaluation of candidate genes related to neuronal apoptosis in late-onset Alzheimer's disease

Moreno-Grau, Sonia, Barneda, Bruna, Carriba, Paulina, Marín, Juan, Sotolongo-Grau, Oscar, Hernández, Isabel, Rosende-Roca, Maitée, Mauleón, Ana, Vargas, Liliana, Espinosa, Ana, Alegret, Montserrat, Rodriguez, Octavio, Ortega, Gemma, Fernández, Maria Victoria, López-Arrieta, Jesús, Tárraga, Lluís, Boada, Mercè, Antúnez, Carmen, López, Joaquin, Ruiz, Agustín and Comella, Joan Xavier 2015. Evaluation of candidate genes related to neuronal apoptosis in late-onset Alzheimer's disease. Journal of Alzheimer's Disease 45 (2) , pp. 621-629. 10.3233/JAD-142721

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The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780; OR = 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer's disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer's disease and human leukocyte antigen.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: IOS Press
ISSN: 1387-2877
Date of Acceptance: 17 December 2014
Last Modified: 17 Mar 2021 02:41

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