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Defects during Mecp2 null embryonic cortex development precede the onset of overt neurological symptoms

Bedogni, Francesco, Cobolli Gigli, Clementina, Pozzi, Davide, Rossi, Riccardo Lorenzo, Scaramuzza, Linda, Rossetti, Grazisa, Pagani, Massimiliano, Kilstrup-Nielsen, Charlotte, Matteoli, Michela and Landsberger, Nicoletta 2016. Defects during Mecp2 null embryonic cortex development precede the onset of overt neurological symptoms. Cerebral Cortex 26 (6) , pp. 2517-2529. 10.1093/cercor/bhv078

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Abstract

MeCP2 is associated with several neurological disorders; of which, Rett syndrome undoubtedly represents the most frequent. Its molecular roles, however, are still unclear, and data from animal models often describe adult, symptomatic stages, while MeCP2 functions during embryonic development remain elusive. We describe the pattern and timing of Mecp2 expression in the embryonic neocortex highlighting its low but consistent expression in virtually all cells and show the unexpected occurrence of transcriptional defects in the Mecp2 null samples at a stage largely preceding the onset of overt symptoms. Through the deregulated expression of ionic channels and glutamatergic receptors, the lack of Mecp2 during early neuronal maturation leads to the reduction in the neuronal responsiveness to stimuli. We suggest that such features concur to morphological alterations that begin affecting Mecp2 null neurons around the perinatal age and become evident later in adulthood. We indicate MeCP2 as a key modulator of the transcriptional mechanisms regulating cerebral cortex development. Neurological phenotypes of MECP2 patients could thus be the cumulative result of different adverse events that are already present at stages when no obvious signs of the pathology are evident and are worsened by later impairments affecting the central nervous system during maturation and maintenance of its functionality.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Oxford University Press
ISSN: 1047-3211
Last Modified: 16 Jun 2020 07:15
URI: https://orca.cardiff.ac.uk/id/eprint/132370

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