The genomic landscape of structural variations and complex events in multiple myeloma

Maura, F., Dawson, K. J., Angelopoulos, N. ORCID: https://orcid.org/0000-0002-7507-9177, Minvielle, S., Martincorena, I., Mitchell, T. J., Fullam, A., Gonzalez, S., Glodzik, D., Szalat, R., Samur, M. K., Fulciniti, M., Tai, Y. T., Magrangeas, F., Moreau, P., Anderson, K., Wedge, D. C., Gerstung, M., Corradini, P., Avet-Loiseau, H., Munshi, N., Campbell, P. J. and Bolli, N. 2018. The genomic landscape of structural variations and complex events in multiple myeloma. Presented at: XV Congress of the Italian Society of Experimental Hematology, Rimini, Italy, 18-20 October 2018. Haematologica. , vol.103 (S3) S14.

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Abstract

Introduction: Multiple Myeloma (MM) initiation and progression is driven by recurrent cytogenetic events, i.e. multiple trisomies or translo cations within the immunoglobulin locus. Gene mutations have been extensively studied, and they are generally involved in late phases of disease development. On the contrary, very little is known about struc tural variations (SV), which are increasingly emerging as critical driver in several cancers.

Item Type:	Conference or Workshop Item - published (Paper)
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
ISSN:	0390-6078
Date of Acceptance:	23 August 2018
Last Modified:	08 Sep 2026 13:05
URI:	https://orca.cardiff.ac.uk/id/eprint/133801

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