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Partitioning the environmental drivers of immunocompetence

Jackson, Joseph A., Friberg, Ida M., Hablützel, Pascal I., Masud, Numair, Stewart, Alexander, Synnott, Rebecca and Cable, Joanne ORCID: https://orcid.org/0000-0002-8510-7055 2020. Partitioning the environmental drivers of immunocompetence. Science of the Total Environment 747 , 141152. 10.1016/j.scitotenv.2020.141152

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Abstract

By determining susceptibility to disease, environment-driven variation in immune responses can affect the health, productivity and fitness of vertebrates. Yet how the different components of the total environment control this immune variation is remarkably poorly understood. Here, through combining field observation, experimentation and modelling, we are able to quantitatively partition the key environmental drivers of constitutive immune allocation in a model wild vertebrate (three-spined stickleback, Gasterosteus aculeatus). We demonstrate that, in natural populations, thermal conditions and diet alone are sufficient (and necessary) to explain a dominant (seasonal) axis of variation in immune allocation. This dominant axis contributes to both infection resistance and tolerance and, in turn, to the vital rates of infectious agents and the progression of the disease they cause. Our results illuminate the environmental regulation of vertebrate immunity (given the evolutionary conservation of the molecular pathways involved) and they identify mechanisms through which immunocompetence and host-parasite dynamics might be impacted by changing environments. In particular, we predict a dominant sensitivity of immunocompetence and immunocompetence-driven host-pathogen dynamics to host diet shifts.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Biosciences
Publisher: Elsevier
ISSN: 0048-9697
Date of First Compliant Deposit: 1 September 2020
Date of Acceptance: 19 July 2020
Last Modified: 07 Nov 2022 11:08
URI: https://orca.cardiff.ac.uk/id/eprint/134592

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