Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach

Mennan, Claire, Hopkins, Timothy, Channon, Alastair, Elliott, Mark, Johnstone, Brian, Kadir, Timor, Loughlin, John, Peffers, Mandy, Pitsillides, Andrew, Sofat, Nidhi, Stewart, Caroline, Watt, Fiona E., Zeggini, Eleftheria, Holt, Cathy ORCID: and Roberts, Sally 2020. The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach. Osteoarthritis and Cartilage Open 2 (3) , 100081. 10.1016/j.ocarto.2020.100081

[thumbnail of 1-s2.0-S2665913120300728-main.pdf]
PDF - Published Version
Available under License Creative Commons Attribution.

Download (590kB) | Preview


Objective This UK-wide OATech Network + consensus study utilised a Delphi approach to discern levels of awareness across an expert panel regarding the role of existing and novel technologies in osteoarthritis research. To direct future cross-disciplinary research it aimed to identify which could be adopted to subcategorise patients with osteoarthritis (OA). Design An online questionnaire was formulated based on technologies which might aid OA research and subcategorisation. During a two-day face-to-face meeting concordance of expert opinion was established with surveys (23 questions) before, during and at the end of the meeting (Rounds 1, 2 and 3, respectively). Experts spoke on current evidence for imaging, genomics, epigenomics, proteomics, metabolomics, biomarkers, activity monitoring, clinical engineering and machine learning relating to subcategorisation. For each round of voting, ≥80% votes led to consensus and ≤20% to exclusion of a statement. Results Panel members were unanimous that a combination of novel technological advances have potential to improve OA diagnostics and treatment through subcategorisation, agreeing in Rounds 1 and 2 that epigenetics, genetics, MRI, proteomics, wet biomarkers and machine learning could aid subcategorisation. Expert presentations changed participants’ opinions on the value of metabolomics, activity monitoring and clinical engineering, all reaching consensus in Round 2. X-rays lost consensus between Rounds 1 and 2; clinical X-rays reached consensus in Round 3. Conclusion Consensus identified that 9 of the 11 technologies should be targeted towards OA subcategorisation to address existing OA research technology and knowledge gaps. These novel, rapidly evolving technologies are recommended as a focus for emergent, cross-disciplinary osteoarthritis research programmes.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Engineering
Publisher: Elsevier
ISSN: 2665-9131
Funders: EPSRC
Date of First Compliant Deposit: 14 September 2020
Date of Acceptance: 28 May 2020
Last Modified: 05 May 2023 11:51

Actions (repository staff only)

Edit Item Edit Item


Downloads per month over past year

View more statistics