Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

Dopamine and glutamate in antipsychotic-responsive compared with antipsychotic-nonresponsive psychosis: a multicenter positron emission tomography and magnetic resonance spectroscopy study (STRATA)

Egerton, Alice, Murphy, Anna, Donocik, Jacek, Anton, Adriana, Barker, Gareth J., Collier, Tracy, Deakin, Bill, Drake, Richard, Eliasson, Emma, Emsley, Richard, Gregory, Catherine J., Griffiths, Kira, Kapur, Shitij, Kassoumeri, Laura, Knight, Laura, Lambe, Emily J. B., Lawrie, Stephen M., Lees, Jane, Lewis, Shôn, Lythgoe, David J., Matthews, Julian, McGuire, Philip, McNamee, Lily, Semple, Scott, Shaw, Alexander D. ORCID: https://orcid.org/0000-0001-5741-7526, Singh, Krish D. ORCID: https://orcid.org/0000-0002-3094-2475, Stockton-Powdrell, Charlotte, Talbot, Peter S., Veronese, Mattia, Wagner, Ernest, Walters, James T. R. ORCID: https://orcid.org/0000-0002-6980-4053, Williams, Stephen R., MacCabe, James H. and Howes, Oliver D. 2021. Dopamine and glutamate in antipsychotic-responsive compared with antipsychotic-nonresponsive psychosis: a multicenter positron emission tomography and magnetic resonance spectroscopy study (STRATA). Schizophrenia Bulletin 47 (2) , pp. 505-516. 10.1093/schbul/sbaa128

[thumbnail of untitled.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (276kB) | Preview

Abstract

The variability in the response to antipsychotic medication in schizophrenia may reflect between-patient differences in neurobiology. Recent cross-sectional neuroimaging studies suggest that a poorer therapeutic response is associated with relatively normal striatal dopamine synthesis capacity but elevated anterior cingulate cortex (ACC) glutamate levels. We sought to test whether these measures can differentiate patients with psychosis who are antipsychotic responsive from those who are antipsychotic nonresponsive in a multicenter cross-sectional study. 1H-magnetic resonance spectroscopy (1H-MRS) was used to measure glutamate levels (Glucorr) in the ACC and in the right striatum in 92 patients across 4 sites (48 responders [R] and 44 nonresponders [NR]). In 54 patients at 2 sites (25 R and 29 NR), we additionally acquired 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine (18F-DOPA) positron emission tomography (PET) to index striatal dopamine function (Kicer, min−1). The mean ACC Glucorr was higher in the NR than the R group after adjustment for age and sex (F1,80 = 4.27; P = .04). This was associated with an area under the curve for the group discrimination of 0.59. There were no group differences in striatal dopamine function or striatal Glucorr. The results provide partial further support for a role of ACC glutamate, but not striatal dopamine synthesis, in determining the nature of the response to antipsychotic medication. The low discriminative accuracy might be improved in groups with greater clinical separation or increased in future studies that focus on the antipsychotic response at an earlier stage of the disorder and integrate other candidate predictive biomarkers. Greater harmonization of multicenter PET and 1H-MRS may also improve sensitivity.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Psychology
Medicine
Cardiff University Brain Research Imaging Centre (CUBRIC)
MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Additional Information: This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/)
Publisher: Oxford University Press
ISSN: 0586-7614
Date of First Compliant Deposit: 14 September 2020
Date of Acceptance: 7 September 2020
Last Modified: 05 Jan 2024 03:09
URI: https://orca.cardiff.ac.uk/id/eprint/134820

Citation Data

Cited 21 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics