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Transition metal free α-C-alkylation of ketones using secondary alcohols

Dambatta, Mubarak B., Santos, Joseph, Bolt, Robert and Morrill, Louis C. ORCID: 2020. Transition metal free α-C-alkylation of ketones using secondary alcohols. Tetrahedron 76 (45) , 131571. 10.1016/j.tet.2020.131571

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A base-mediated α-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-α-C-alkylation in high isolated yields (23 examples, 65% average yield).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: Elsevier
ISSN: 0040-4020
Funders: Tertiary Education Trust Fund (TETFund) and Cardiff University
Date of First Compliant Deposit: 14 September 2020
Date of Acceptance: 1 September 2020
Last Modified: 07 Nov 2023 08:50

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