Transition metal free α-C-alkylation of ketones using secondary alcohols

Dambatta, Mubarak B., Santos, Joseph, Bolt, Robert and Morrill, Louis C. ORCID: https://orcid.org/0000-0002-6453-7531 2020. Transition metal free α-C-alkylation of ketones using secondary alcohols. Tetrahedron 76 (45) , 131571. 10.1016/j.tet.2020.131571

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Abstract

A base-mediated α-C-alkylation of ketones with secondary alcohols has been developed. This transition metal free approach employs KOt-Bu as the base and exhibits a broad scope, allowing a range of commodity aliphatic secondary alcohols and 1-arylethanols to be employed as alkylating agents. Aryl methyl ketones undergo selective mono-α-C-alkylation in high isolated yields (23 examples, 65% average yield).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	Elsevier
ISSN:	0040-4020
Funders:	Tertiary Education Trust Fund (TETFund) and Cardiff University
Date of First Compliant Deposit:	14 September 2020
Date of Acceptance:	1 September 2020
Last Modified:	25 Nov 2024 04:30
URI:	https://orca.cardiff.ac.uk/id/eprint/134828

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