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Inflammasome signaling and other factors implicated in atherosclerosis development and progression

Nazarian Samani, Zeinab, Sewell, Robert and Rafieian Kopaei, Mahmoud 2020. Inflammasome signaling and other factors implicated in atherosclerosis development and progression. Current Pharmaceutical Design 26 (22) , pp. 2583-2590. 10.2174/1381612826666200504115045

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Abstract

Chronic inflammation plays an extensive role in the onset and progression of metabolic disorders such as atherosclerosis, type 2 diabetes, gout and obesity. Atherosclerosis accounts for upwards of 70% mortality in patients with type 2 diabetes and is also a chronic condition that causes atrial stenosis due to a lipometabolism imbalance. The purpose of this article is to consider the inflammatory factors implicated in atherosclerosis and their role in the development and progression of this vascular disease. The inflammasome signaling pathway is an important inflammatory mechanism involved in the development of atherosclerosis. The most important inflammasome pathway in this respect is NLRP3 (Nucleotide-binding oligomerization domain (NOD)-like receptor with a pyrin domain 3), whose activation leads to the generation of important inflammatory cytokines including interleukins 1β and 18 (IL-1β and 18). The activities of these mature cytokines and inflammatory factors produced by other inflammatory pathways, lead to arterial inflammation and eventually arterial occlusion, which can result in life-threatening complications such as myocardial infarction and stroke. Therefore, it is essential to seek out more precise mechanisms for activation of inflammasomes and other inflammatory pathways for the development of therapeutic strategies for atherosclerosis.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Uncontrolled Keywords: Atherosclerosis, NLRP3, Inflammasome, Inflammation, Cardiovascular disease
Publisher: Bentham Science Publishers
ISSN: 1381-6128
Funders: unspecified
Date of First Compliant Deposit: 2 November 2020
Date of Acceptance: 1 August 2020
Last Modified: 10 Oct 2021 12:46
URI: https://orca.cardiff.ac.uk/id/eprint/136074

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