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Location, function and role of stromal cell-derived factors and possible implications in cancer

Gong, Wenjing, Martin, Tracey A., Sanders, Andrew J., Jiang, Aihua, Sun, Ping and Jiang, Wen G. 2021. Location, function and role of stromal cell-derived factors and possible implications in cancer. International Journal of Molecular Medicine 47 (2) , pp. 435-443. 10.3892/ijmm.2020.4811

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Abstract

Despite improvements in therapy and management, cancer represents and remains a major cause of mortality and morbidity worldwide. Although genetics serve an important role in tumorigenesis and tumour progression, the tumour microenvironment (TME) in solid tumours is also important and has been indicated to contribute to these processes. Stromal cell‑derived factors (SDFs) represent an important family within the TME. The family includes SDF‑1, SDF‑2, SDF2‑like 1 (SDF2L1), SDF‑3, SDF‑4 and SDF‑5. SDF‑1 has been demonstrated to act as a positive regulator in a number of types of tumour, such as oesophago‑gastric, pancreatic, lung, breast, colorectal and ovarian cancer, while the biology and functions of other members of the SDF family, including SDF‑2, SDF2L1, SDF‑4 and SDF‑5, in cancer are different, complex and controversial, and remain mainly unknown. Full identification and understanding of the SDFs across multiple types of cancer is required to elucidate their function and establish potential key targets in cancer.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Additional Information: This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) License.
Publisher: Spandidos Publications
ISSN: 1107-3756
Funders: Cardiff University China Scholarship
Date of First Compliant Deposit: 9 February 2021
Date of Acceptance: 29 October 2020
Last Modified: 07 Jan 2022 02:17
URI: https://orca.cardiff.ac.uk/id/eprint/136552

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