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Systematic review and meta-analysis of tobacco use as a risk factor for prosthetic joint infection after total hip replacement

Bojan, Bsmah, Perni, Stefano and Prokopovich, Polina ORCID: 2020. Systematic review and meta-analysis of tobacco use as a risk factor for prosthetic joint infection after total hip replacement. Arthroplasty Today 6 (4) , pp. 959-971. 10.1016/j.artd.2020.07.011

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Background A prosthetic joint infection (PJI) is one of the possible complications after total hip arthroplasty (THA). Several studies, but not all, have reported smoking as a risk factor of PJIs in orthopaedic surgery. This study summarizes the most recent evidence using a systematic review of whether tobacco use (not only tobacco smoking) is a risk factor in developing PJIs, specifically after THA. Methods Ovid Medline, EMBASE, Scopus, Web of Science, and Cochrane databases were searched from inception to July 2019 to identify case-control studies that examined the PJI risk in tobacco users and tobacco nonusers undergoing THA. Publication bias was also assessed through funnel plots. Results Searches identified 2689 articles, and 10 of these, involving a total of 20,640 patients, met the inclusion criteria. The overall odds ratio (pooled odds ratio) to develop either a superficial infection, a deep infection, or an infection requiring revision surgery for tobacco users vs nonusers was 1.54 (95% confidence interval: 1.25-1.91) when a fixed-effect model was used and 1.56 (95% confidence interval: 1.10-2.21) when a random-effect model was used. No publication bias was observed among the identified studies. Conclusions The findings of the study indicated that tobacco use is associated with a higher risk of PJIs in patients undergoing THA.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Pharmacy
ISSN: 2352-3441
Date of First Compliant Deposit: 7 December 2020
Date of Acceptance: 9 July 2020
Last Modified: 11 Nov 2023 17:59

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