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A robust Pd-catalyzed C–S cross-coupling process enabled by ball-milling

Jones, Andrew C., Nicholson, William I., Smallman, Harry R. and Browne, Duncan L. ORCID: 2020. A robust Pd-catalyzed C–S cross-coupling process enabled by ball-milling. Organic Letters 22 (19) , pp. 7433-7438. 10.1021/acs.orglett.0c02418

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An operationally simple mechanochemical C–S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Publisher: American Chemical Society
ISSN: 1523-7060
Last Modified: 11 Mar 2023 02:52

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