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Increased pfmdr1 copy number and sequence polymorphisms in lasmodium falciparum Isolates from Sudanese malaria patients treated with artemether-lumefantrine

Gadalla, Nahla B., Adam, Ishag, Elzaki, Salah-Eldin, Bashir, Sahar, Mukhtar, Izdihar, Oguike, Mary, Gadalla, Amal, Mansour, Fathi, Warhurst, David, El-Sayed, Badria B. and Sutherland, Colin J. 2011. Increased pfmdr1 copy number and sequence polymorphisms in lasmodium falciparum Isolates from Sudanese malaria patients treated with artemether-lumefantrine. Antimicrobial Agents and Chemotherapy 55 (11) , pp. 5408-5411. 10.1128/AAC.05102-11

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Abstract

Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further individuals were parasite positive by PCR during follow-up. Polymorphisms in pfatpase6 and pfmdr1 were evaluated by DNA sequencing. One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: American Society for Microbiology
ISSN: 0066-4804
Date of First Compliant Deposit: 15 January 2021
Date of Acceptance: 24 August 2011
Last Modified: 15 Jan 2021 17:05
URI: https://orca.cardiff.ac.uk/id/eprint/137632

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