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Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis

Gifford, George, Crossley, Nicolas, Morgan, Sarah, Kempton, Matthew J., Dazzan, Paola, Modinos, Gemma, Azis, Matilda, Samson, Carly, Bonoldi, Ilaria, Quinn, Beverly, Smart, Sophie E. ORCID:, Antoniades, Mathilde, Bossong, Matthijs G., Broome, Matthew R., Perez, Jesus, Howes, Oliver D., Stone, James M., Allen, Paul, Grace, Anthony A. and McGuire, Philip 2021. Integrated metastate functional connectivity networks predict change in symptom severity in clinical high risk for psychosis. Human Brain Mapping 42 (2) , pp. 439-451. 10.1002/hbm.25235

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The ability to identify biomarkers of psychosis risk is essential in defining effective preventive measures to potentially circumvent the transition to psychosis. Using samples of people at clinical high risk for psychosis (CHR) and Healthy controls (HC) who were administered a task fMRI paradigm, we used a framework for labelling time windows of fMRI scans as ‘integrated’ FC networks to provide a granular representation of functional connectivity (FC). Periods of integration were defined using the ‘cartographic profile’ of time windows and k‐means clustering, and sub‐network discovery was carried out using Network Based Statistics (NBS). There were no network differences between CHR and HC groups. Within the CHR group, using integrated FC networks, we identified a sub‐network negatively associated with longitudinal changes in the severity of psychotic symptoms. This sub‐network comprised brain areas implicated in bottom‐up sensory processing and in integration with motor control, suggesting it may be related to the demands of the fMRI task. These data suggest that extracting integrated FC networks may be useful in the investigation of biomarkers of psychosis risk.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Wiley
ISSN: 1065-9471
Date of First Compliant Deposit: 14 January 2021
Date of Acceptance: 29 September 2020
Last Modified: 06 May 2023 03:41

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