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5-HT/GABA interaction in neurodevelopment and plasticity

Deidda, Gabriele, Pierucci, Massimo, Crunelli, Vincenzo ORCID: and Di Giovanni, Giuseppe 2021. 5-HT/GABA interaction in neurodevelopment and plasticity. Progress in Brain Research, Vol. 259. ELSEVIER SCIENCE BV, pp. 287-317. (10.1016/bs.pbr.2021.01.009)

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The adult brain is the result of a multistages complex neurodevelopmental process involving genetic, molecular and microenvironmental factors as well as diverse patterns of electrical activity. In the postnatal life, immature neuronal circuits undergo an experience-dependent maturation during critical periods of plasticity, but the brain still retains plasticity during adult life. In all these stages, the neurotransmitter GABA plays a pivotal role. In this chapter, we will describe the interaction of 5-HT with GABA in regulating neurodevelopment and plasticity.

Item Type: Book Section
Date Type: Publication
Status: Published
Schools: Biosciences
ISSN: 0079-6123
Last Modified: 09 Nov 2022 10:07

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