Oxidative trifluoromethylation of unactivated olefins: an efficient and practical synthesis of α‐trifluoromethyl‐substituted ketones

Deb, Arghya, Manna, Srimanta, Modak, Atanu, Patra, Tuhin, Maity, Soham and Maiti, Debabrata 2013. Oxidative trifluoromethylation of unactivated olefins: an efficient and practical synthesis of α‐trifluoromethyl‐substituted ketones. Angewandte Chemie International Edition 52 (37) , pp. 9747-9750. 10.1002/anie.201303576

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Abstract

An economical approach to α‐CF3‐substituted ketones, which are important intermediates in synthetic and medicinal chemistry, employs olefins and the readily available Langlois reagent (CF3SO2Na). The reaction is operationally simple, proceeds at room temperature, and exhibits an excellent tolerance toward a wide variety of functional groups.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Wiley
ISSN:	1433-7851
Last Modified:	06 May 2023 01:58
URI:	https://orca.cardiff.ac.uk/id/eprint/138421

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