Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

The effects of midazolam on the acquisition and expression of fructose- and maltodextrin-based flavour preferences

Dwyer, Dominic M. ORCID: 2009. The effects of midazolam on the acquisition and expression of fructose- and maltodextrin-based flavour preferences. Pharmacology, Biochemistry and Behavior 91 (4) , pp. 503-510. 10.1016/j.pbb.2008.09.001

Full text not available from this repository.


The effects of the benzodiazepine agonist midazolam on the acquisition and expression of flavour preferences were investigated. Rats (Experiment 1) were given one-bottle training with one flavoured solution (CS+) mixed with either fructose or maltodextrin and another solution (CS−) presented alone. Animals receiving 1 mg/kg midazolam during training consumed more CS− than did animals receiving vehicle injections although there was no drug effect on CS+ consumption. In two-bottle tests the CS+ was preferred to the CS− with the preference being larger in fructose trained animals. Midazolam (0.3–3 mg/kg) increased total intake but not CS+ preference. Training under midazolam reduced the CS+ preference when fructose, but not maltodextrin, was the reinforcer. In Experiment 2 training consumption was restricted to 10 ml/session. This removed the difference in CS+ preference between reinforcer types but otherwise the results were as in Experiment 1. The midazolam induced attenuation of fructose-based preferences might reflect an increase in CS− palatability during training which would reduce the difference between the reinforced and non-reinforced solutions. As maltodextrin supports preferences due to post-ingestive effects manipulation of palatability should be ineffective. Midazolam does not influence the expression of conditioned flavour preferences despite prior evidence that benzodiazepine agonists enhance palatability.

Item Type: Article
Status: Published
Schools: Psychology
Subjects: Q Science > QP Physiology
Uncontrolled Keywords: Flavour–flavour learning; Flavour–nutrient learning; Sweet taste; Post-ingestive effects
Publisher: Elsevier
ISSN: 0091-3057
Last Modified: 18 Oct 2022 13:26

Citation Data

Cited 8 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item