A highly sensitive radial diffusion measurement method for white matter tract investigation

Fasano, Fabrizio, Bozzali, Marco, Cercignani, Mara ORCID: https://orcid.org/0000-0002-4550-2456 and Hagberg, Gisela E. 2009. A highly sensitive radial diffusion measurement method for white matter tract investigation. Magnetic Resonance Imaging 27 (4) , pp. 519-530. 10.1016/j.mri.2008.08.005

Full text not available from this repository.

Abstract

This article describes a novel approach for local estimation of the radial diffusion coefficient (D(perpendicular)) in white matter (WM) regions containing well-oriented nervous fibers. The method is based on the assumption that the diffusion process in well-organized WM regions responds to a cylindrical symmetry. The increased precision in the estimation of D(perpendicular) provided by this local approach compared to standard techniques based on diffusion tensor imaging is demonstrated using numerical simulations. An in vivo validation of the technique is also provided, showing its application to the corpus callosum of six healthy volunteers, highlighting the sensitivity of the method. Assuming that D(perpendicular) is sensitive to myelin integrity, our technique has the potential to investigate pathophysiological aspects of several neurological and psychiatric disorders with improved precision in targeted WM tracts.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Psychology Cardiff University Brain Research Imaging Centre (CUBRIC)
Publisher:	Elsevier
ISSN:	0730-725X
Last Modified:	09 Nov 2022 10:26
URI:	https://orca.cardiff.ac.uk/id/eprint/139485

Citation Data

Cited 1 time in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item