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N-Heterocyclic carbenes as “smart” gold nanoparticle stabilizers: state-of-the art and perspectives for biomedical applications

Thomas, Sophie R. and Casini, Angela 2021. N-Heterocyclic carbenes as “smart” gold nanoparticle stabilizers: state-of-the art and perspectives for biomedical applications. Journal of Organometallic Chemistry 938 , 121743. 10.1016/j.jorganchem.2021.121743

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Abstract

The unique properties and high synthetic flexibility of N-heterocyclic carbenes (NHCs) have made them highly attractive tools for the development of new nanomaterials and the fundamental study of their properties. In this review, we focus on the case of NHC-stabilized gold nanoparticles (NHC@AuNPs) with potential for biological applications. AuNPs are ubiquitous in biomedicine, where they serve as versatile scaffolds for drug/gene delivery, biosensing, imaging and therapy. In this context, our review aims at presenting an overview of the relatively few studies reporting on the synthesis and characterization of NHC@AuNPs, with emphasis on the strategies adopted to achieve water-soluble biocompatible nanoparticles. Overall, the possible combinatorial design of NHC ligand shell functionality opens to new perspectives for this relatively unexplored research area.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: Elsevier
ISSN: 0022-328X
Date of First Compliant Deposit: 8 April 2021
Date of Acceptance: 8 February 2021
Last Modified: 19 Feb 2022 16:16
URI: https://orca.cardiff.ac.uk/id/eprint/140375

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