Electrochemistry in flow for drug discovery

Winterson, Bethan and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2020. Electrochemistry in flow for drug discovery. Topics in Medicinal Chemistry, Vol. 38. Springer, pp. 121-172. (10.1007/7355_2021_115)

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Abstract

Electrochemistry, first proposed over two centuries ago, is one of the oldest forms of reaction set-ups explored in a laboratory. Electrochemical methods possess many benefits in comparison with traditional reagent-based transformations, such as (1) innate scalability and sustainability, (2) high functional group tolerance, (3) mild reaction conditions, (4) high versatility and the ability to carry out reactions that were otherwise inaccessible. While preparative organic electrosynthesis has been an active area of research over the past century, the adoption of electrochemical methods has been remarkably under-resourced, particularly in drug discovery. This phenomenon seems to arise from the lack of expertise in this area and the seemingly complex reaction set-ups.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Springer
ISSN:	1862-2461
Date of Acceptance:	17 March 2021
Last Modified:	23 Nov 2022 13:13
URI:	https://orca.cardiff.ac.uk/id/eprint/140560

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