Belsher, Bradley, Beech, Erin, Reddy, Madhavi, Smolenski, Derek, Rauch, Sheila, Kelber, Marija, Issa, Fuad, Lewis, Catrin ORCID: https://orcid.org/0000-0002-3818-9377 and Bisson, Jonathan ORCID: https://orcid.org/0000-0001-5170-1243 2021. Advances in repetitive transcranial magnetic stimulation for posttraumatic stress disorder: a systematic review. Journal of Psychiatric Research 138 , pp. 598-606. 10.1016/j.jpsychires.2021.05.011 |
PDF
- Accepted Post-Print Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (344kB) |
Abstract
Repetitive transcranial magnetic stimulation (rTMS) as a treatment for posttraumatic stress disorder (PTSD) has gained interest over the past two decades. However, it has yet to be recommended in major treatment guidelines. We conducted a systematic review of randomized controlled trials to examine the efficacy of rTMS for PTSD. Thirteen studies with 549 participants were included in this review. We compared the effects of (1) rTMS versus sham, and (2) high-frequency (HF) versus low-frequency (LF) rTMS, on posttreatment PTSD scores and other secondary outcomes. We calculated the standardized mean differences (SMD) to determine the direction of effects, and unstandardized mean differences to estimate the magnitude of efficacy. At post-treatment, rTMS was superior to sham comparison in reducing PTSD (SMD = −1.13, 95% CI: −2.10 to −0.15) and depression severity (SMD = −0.83, 95% CI: −1.30 to −0.36). The quality of evidence, however, was rated very low due to small samples sizes, treatment heterogeneity, inconsistent results, and an imprecise pooled effect. HF rTMS was associated with slightly improved, albeit imprecise, outcomes compared to LF rTMS on PTSD (SMD = −0.19, 95% CI: −1.39 to 1.00) and depression (SMD = −1.09, 95% CI: −1.65 to −0.52) severity. Further research is required to advance the evidence on this treatment.
Item Type: | Article |
---|---|
Date Type: | Publication |
Status: | Published |
Schools: | Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG) |
Publisher: | Elsevier |
ISSN: | 0022-3956 |
Date of First Compliant Deposit: | 5 May 2021 |
Date of Acceptance: | 1 May 2021 |
Last Modified: | 07 Nov 2023 01:06 |
URI: | https://orca.cardiff.ac.uk/id/eprint/140951 |
Citation Data
Cited 4 times in Scopus. View in Scopus. Powered By Scopus® Data
Actions (repository staff only)
Edit Item |