Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A prospective comparison of multidisciplinary treatment of oesophageal cancer with curative intent in a UK cancer network

Adams, R., Morgan, M., Mukherjee, S., Brewster, A., Maughan, T., Morrey, D., Havard, T., Lewis, W., Clark, G., Roberts, S., Vachtsevanos, L., Leong, J., Hardwick, R., Carey, D. and Crosby, T. 2007. A prospective comparison of multidisciplinary treatment of oesophageal cancer with curative intent in a UK cancer network. EJSO - European Journal of Surgical Oncology 33 (3) , pp. 307-313. 10.1016/j.ejso.2006.10.026

Full text not available from this repository.

Abstract

AimsCombined modality therapy (with chemotherapy ± radiotherapy) has become a standard treatment for locally advanced oesophageal cancer. However, there appears to be no compelling evidence for one treatment type or combination to suit all and at this time the clinical multi-disciplinary team (MDT) forms an important role in selecting optimal therapies for the individual. This prospective comparison in one cancer network, looks at the outcomes of this decision making process.MethodsOver a five year period 1998–2003, data were prospectively collected on all 330 consecutive patients, referred to a tertiary specialised MDT for whom curative treatment was the planned intent. Patients were managed according to an agreed local protocol and allocated to receive one of 5 treatments: surgery alone (S), pre-operative chemotherapy (C + S), pre-operative chemo-radiotherapy (CRT + S), definitive chemo-radiotherapy (CRT) and radiotherapy alone (RT).ResultsThe 2 and 5 year survival for all patients receiving potentially curative treatment were 49% and 26% respectively. With 2 and 5 year survival for S, CRT + S, C + S, CRT and RT being 53,21; 57,40; 37,27; 50,27; 23,0 months respectively. Of the surgical therapies, mortality was highest in the CRT + S group, versus C + S and S; 12.5%, 1.6%, 4.5% respectively (p = 0.025). Non-surgical based therapies had more than double the incidence of local relapses compared to surgical based therapies; however the CRT group had an overall survival comparable with S alone. The commonest sites of distant relapse were liver (56%), lung (38%), bone (32%) and non-regional lymph nodes (24%).ConclusionThe results suggest that in patients who are deemed unfit for surgical intervention, definitive chemoradiotherapy remains a viable alternative; they also lend further support to selected case triple modality therapy. These areas should be further examined in the context of randomised controlled phase III trials.

Item Type: Article
Date Type: Published Online
Status: Published
Schools: Medicine
Centre for Trials Research (CNTRR)
Publisher: WB Saunders
ISSN: 0748-7983
Date of Acceptance: 16 October 2006
Last Modified: 07 Jun 2021 13:45
URI: https://orca.cardiff.ac.uk/id/eprint/141124

Citation Data

Cited 31 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item