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Editorial: The complexity of primary antibody deficiencies

Quinti, Isabella, Spadaro, Giuseppe, Jolles, Stephen and Condino-Neto, Antonio 2021. Editorial: The complexity of primary antibody deficiencies. Frontiers in Immunology 12 , 635482. 10.3389/fimmu.2021.635482

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Abstract

Primary antibody deficiencies represent by far the largest group of primary immunodeficiencies (PID) at 56% (ESID Registry), however the proportion of patients in whom antibody deficiency represents a component of their condition is greater still at around 75% (1). It has become clear over recent years that while the vast majority of such patients experience recurrent infections a significant proportion are also affected by non-infectious dysregulatory complications which include malignancy, autoimmunity, inflammation and allergy (Figure 1). The increasingly complex manifestations of Primary Antibody Deficiencies have a major impact on the clinical management of patients and raise diagnostic and therapeutic challenges (2). This Research Topic draws together a series of reports focusing on a range of these non-infectious complications and their clinical implications.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Frontiers Media
ISSN: 1664-3224
Funders: N/A
Date of First Compliant Deposit: 17 May 2021
Date of Acceptance: 12 March 2021
Last Modified: 17 May 2021 13:00
URI: https://orca.cardiff.ac.uk/id/eprint/141315

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