Cardiff University | Prifysgol Caerdydd ORCA
Online Research @ Cardiff 
WelshClear Cookie - decide language by browser settings

A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients

Davy, Catrina and Heathcote, Sharron 2021. A systematic review of interventions to mitigate radiotherapy-induced oral mucositis in head and neck cancer patients. Supportive Care in Cancer 29 (4) , pp. 2187-2202. 10.1007/s00520-020-05548-0

[thumbnail of Davy-Heathcote2021_Article_ASystematicReviewOfInterventio.pdf]
Preview
PDF - Published Version
Available under License Creative Commons Attribution.

Download (571kB) | Preview

Abstract

Background Oral mucositis is a debilitating consequence of radiotherapy in patients with head and neck cancers. Radiation-induced oral mucositis (RIOM) can cause pain and weight loss, reduce quality of life and affect treatment outcomes. Methods A systematic review was undertaken to identify and examine the efficacy of low-cost interventions to mitigate RIOM and to develop clinical guidelines based on the evidence. Results The author identified three interventions: benzydamine hydrochloride mouth rinse (BHM), honey and oral glutamine (OG). The search identified twenty-four studies in total. Four studies examined BHM; all findings were favourable, although only one had moderate methodological quality, and the rest were low. The product was poorly tolerated by some participants in one study. Twelve studies examined honey. Eleven of these had favourable results; two studies had moderate methodological quality, and the rest were low. Eight studies examined OG. Six of these had favourable results; two studies had moderate methodological quality, and the rest were low. Conclusion The author cannot recommend BHM to mitigate RIOM due to the overall low quality of the studies and poor tolerance to the product. The author cannot recommend honey to mitigate RIOM due to weak evidence supporting the intervention. The author can recommend OG to mitigate RIOM. There is a need for high-quality studies with a consensus of the methodology to reduce heterogeneity and examination of the cost-effectiveness of the interventions.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: Springer Verlag (Germany)
ISSN: 0941-4355
Date of First Compliant Deposit: 14 May 2021
Date of Acceptance: 21 May 2020
Last Modified: 20 May 2021 14:45
URI: https://orca.cardiff.ac.uk/id/eprint/141340

Citation Data

Cited 5 times in Scopus. View in Scopus. Powered By Scopus® Data

Actions (repository staff only)

Edit Item Edit Item

Downloads

Downloads per month over past year

View more statistics