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Cu(II)-mediated ortho-C-H amination of arenes with free amines

Kumar, M., Verma, S., Mishra, P.K. and Verma, A.K. 2019. Cu(II)-mediated ortho-C-H amination of arenes with free amines. Journal of Organic Chemistry 84 (12) , pp. 8067-8079. 10.1021/acs.joc.9b00931

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Copper-mediated direct ortho-C–H amination of arenes has been accomplished with the aid of easily removable bidentate pyridine N-oxide as a directing group. The use of free cyclic secondary amines and anilines as aminating agents and inexpensive copper acetate makes the strategy more effective and favorable from the economic point of view. This reaction is compatible with a wide range of functional groups to synthesize a variety of amine-containing products of high interest. This method also allows the short synthesis of the central scaffold of pharmaceutically relevant Staphylococcus aureus Sortase A inhibitors.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Publisher: American Chemical Society
ISSN: 0022-3263
Last Modified: 25 May 2021 11:28

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