Mishra, Pawan K. ORCID: https://orcid.org/0000-0003-1141-3487, Verma, Shalini, Kumar, Manoj and Verma, A.K. 2018. Base-mediated direct transformation of N-propargylamines into 2,3,5-trisubstituted 1 H-pyrroles. Organic Letters 20 (22) , pp. 7182-7185. 10.1021/acs.orglett.8b03112 |
Official URL: http://dx.doi.org/10.1021/acs.orglett.8b03112
Abstract
An efficient and base-mediated intramolecular cyclization of N-propargylamines for the synthesis of structurally diversified pyrroles in high yield has been described. The developed methodology is broadly applicable and is tolerated by a variety of functional groups. Key intermediates of natural product discoipyrrole C as well as HMG-CoA-reductase inhibitor have been successfully synthesized using developed chemistry. The proposed mechanism was supported by control experiments.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
Last Modified: | 09 Nov 2022 10:59 |
URI: | https://orca.cardiff.ac.uk/id/eprint/141409 |
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