Verma, S., Kumar, M., Mishra, P. K. ORCID: https://orcid.org/0000-0003-1141-3487 and Verma, A. K. 2019. Metal-free carbonyl-assisted regioselective hydration of alkynes: an access to dicarbonyls. Organic Letters 21 (13) , pp. 5059-5063. 10.1021/acs.orglett.9b01649 |
Official URL: http://doi.org/10.1021/acs.orglett.9b01649
Abstract
Metal-free regioselective hydration of o-alkynylaldehydes with the assistance of neighboring carbonyl oxygen is disclosed. The developed protocol provides a facile route to synthesize a series of multisubstituted carbonyl containing scaffolds that enable the potential application toward the synthesis of highly diversified 5-azaindoles. γ-Carbolines and 2,8-diazacarbazoles can also be accessed directly without isolating the dicarbonyl compounds. The developed methodology is operationally simple and environment-friendly, tolerates a wide variety of functional groups, and is applicable toward large scale synthesis.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Chemistry |
Publisher: | American Chemical Society |
ISSN: | 1523-7060 |
Last Modified: | 09 Nov 2022 10:59 |
URI: | https://orca.cardiff.ac.uk/id/eprint/141412 |
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