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Medical algorithm: diagnosis and management of antibody immunodeficiencies

Sedivá, Anna, Milota, Tomás, Litzman, Jirí, Quinti, Isabella, Meyts, Isabelle, Burns, Siobhan and Jolles, Stephen 2021. Medical algorithm: diagnosis and management of antibody immunodeficiencies. Allergy 76 (12) , pp. 3841-3844. 10.1111/all.14961

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Primary antibodydeficiencies (PAD) constitute the majority of all primary immunodeficiency diseases (PID) also termed in born errors of immunity (IEI). This category (PAD) representsaround 52% of all IEI and the proportion overall is still greater given that antibody deficiency is a component of other groups including combined and severe combined immunodeficiencies (SCID), autoinflammatory disorders, diseases of immune dysregulation and other well defined PIDs(1,2). Secondary antibody deficiencies (SAD) represent a larger and expanding number of individuals resulting from the use of a wide range of immunosuppressive therapies, in particular those targeting B cells, and may also result from renal orgastrointestinal immunoglobulin losses, infections, for example HIVormalaria,malnutritionorothers(3).

Item Type: Article
Date Type: Publication
Status: Published
Schools: Medicine
Publisher: John Wiley and Sons
ISSN: 0105-4538
Date of First Compliant Deposit: 2 June 2021
Date of Acceptance: 12 May 2021
Last Modified: 15 Nov 2023 14:53

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