What are the potential roles of nuclear perlecan and other heparan sulphate proteoglycans in the normal and malignant phenotype

Hayes, Anthony J. and Melrose, James 2021. What are the potential roles of nuclear perlecan and other heparan sulphate proteoglycans in the normal and malignant phenotype. International Journal of Molecular Sciences 22 (9) , 4415. 10.3390/ijms22094415

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Abstract

The recent discovery of nuclear and perinuclear perlecan in annulus fibrosus and nucleus pulposus cells and its known matrix stabilizing properties in tissues introduces the possibility that perlecan may also have intracellular stabilizing or regulatory roles through interactions with nuclear envelope or cytoskeletal proteins or roles in nucleosomal-chromatin organization that may regulate transcriptional factors and modulate gene expression. The nucleus is a mechano-sensor organelle, and sophisticated dynamic mechanoresponsive cytoskeletal and nuclear envelope components support and protect the nucleus, allowing it to perceive and respond to mechano-stimulation. This review speculates on the potential roles of perlecan in the nucleus based on what is already known about nuclear heparan sulphate proteoglycans. Perlecan is frequently found in the nuclei of tumour cells; however, its specific role in these diseased tissues is largely unknown. The aim of this review is to highlight probable roles for this intriguing interactive regulatory proteoglycan in the nucleus of normal and malignant cell types.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
Publisher:	MDPI
ISSN:	1422-0067
Date of First Compliant Deposit:	15 June 2021
Date of Acceptance:	19 April 2021
Last Modified:	05 May 2023 12:32
URI:	https://orca.cardiff.ac.uk/id/eprint/141919

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